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  Morphology of Crohn’s Disease The morphology of Crohn’s disease refers to the structural and microscopic changes observed in the gastrointestinal (GI) tract during the disease. These changes can be seen through gross examination (macroscopy) and microscopic (histological) analysis. Crohn’s disease shows distinct morphological features that help differentiate it from other types of inflammatory bowel diseases, especially ulcerative colitis .  1. Gross Morphology (Macroscopic Features) Key Macroscopic Features of Crohn’s Disease : Feature Description Segmental involvement ("skip lesions") Diseased segments are interspersed with normal bowel segments Transmural inflammation Inflammation involves the entire thickness of the bowel wall Thickened bowel wall Due to inflammation, edema, fibrosis, and muscular hypertrophy Cobblestone appearance Mucosal ulcerations with raised areas of edematous tissue give a cobblestone-like look Fissures and ulcer...