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What is Lambert-Eaton Syndrome? Understanding This Rare Neuromuscular Condition That Affects Muscle Strength Imagine waking up with muscles that feel unusually weak — especially in your legs — and as the day goes on, instead of worsening like in most fatigue-related illnesses, your strength oddly improves. This is one of the key signs of Lambert-Eaton Myasthenic Syndrome (LEMS) , a rare autoimmune disorder that interferes with nerve-muscle communication. Though uncommon, Lambert-Eaton Syndrome can be life-altering. Understanding it can lead to earlier diagnosis and better outcomes for those affected. In this article, we’ll explore what LEMS is, how it differs from similar conditions like Myasthenia Gravis, and what treatments are available. Definition Lambert-Eaton Myasthenic Syndrome (LEMS) is a rare autoimmune neuromuscular disorder where the immune system disrupts the way nerves communicate with muscles. This leads to muscle weakness , particularly in the legs and arms . ...