what are the pathogenesis of asthma?
Pathogenesis of Asthma a detailed guide Asthma is a chronic inflammatory disease of the airways characterized by Recurrent episodes of wheezing , dyspnea , chest tightness , and cough Reversible airflow obstruction Airway hyperresponsiveness to various stimuli The pathogenesis of asthma involves complex interactions between genetic and environmental factors, leading to airway inflammation, bronchial hyperresponsiveness, and episodic bronchoconstriction. Pathogenesis of Asthma 1. Genetic Predisposition Individuals with atopy (a tendency to develop allergic diseases) are more likely to develop allergic (extrinsic) asthma . Associated genes: IL-4, IL-5, IL-13 , ADAM33 , and HLA genes . 2. Environmental Triggers Allergens : dust mites, pollen, pet dander, mold Infections : especially viral respiratory infections Pollutants : smoke, fumes, cold air Exercise : especially in cold or dry environments Drugs : aspirin (in aspirin-sensitive asthma) ...