What is osteogenesis imperfecta?
What is Osteogenesis Imperfecta? | Causes, Types, Symptoms & Treatment [2025 Guide] Osteogenesis Imperfecta (OI) , also known as “brittle bone disease,” is a rare genetic disorder characterized by fragile bones that break easily , often with little or no trauma. It affects the production of collagen , a key protein that provides strength and structure to bones and connective tissues. This comprehensive 2025 guide explains everything you need to know about osteogenesis imperfecta, including its types, causes, symptoms, diagnosis, and treatment options. 🧬 What is Osteogenesis Imperfecta? Osteogenesis Imperfecta is a hereditary connective tissue disorder . It primarily affects the bones , but may also involve the teeth, skin, ligaments, and eyes . The condition is caused by mutations in genes—mostly COL1A1 or COL1A2 —that control the production of type I collagen . As a result, bones become brittle, leading to frequent fractures and skeletal deformities. 🔢 Types of Osteogen...