allaboutdpt

 Von Willebrand disease Von Willebrand disease (VWD) is the most common inherited bleeding disorder. It occurs due to a deficiency or dysfunction of von Willebrand factor (vWF) — a protein that plays a critical role in blood clotting. Causes of Von Willebrand Disease Von Willebrand disease is primarily a genetic disorder , meaning it is usually inherited from one or both parents. The condition occurs when there is a deficiency or abnormal function of von Willebrand factor (vWF) , a protein that helps blood clot properly. This protein plays a key role in the initial stages of blood clotting by helping platelets stick to the walls of damaged blood vessels and stabilizing factor VIII, another important clotting protein. The most common form of the disease, Type 1 , is caused by a partial deficiency of vWF and is typically inherited in an autosomal dominant pattern , which means only one copy of the altered gene is enough to cause the disorder. Type 2 results from structural or func...